59 Results for "

Tephrosia vogelii Hook. f.

" in MedChemExpress (MCE) Product Catalog:
Products (59)

59 Results for "Tephrosia vogelii Hook. f." in MCE Product Catalog:

6
Corynoxeine
Corynoxeine
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6 Publications Verification
Art. -Nr.: HY-N0590
CAS. Nr.: 630-94-4
Category:  

Cardiovascular Disease Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Disease Research Fields Indole Alkaloids

Target:  

ERK

Corynoxeine, isolated from the hook of Uncaria rhynchophylla, is a potent ERK1/ERK2 inhibitor of key PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation.
3
Triptonide
Triptonide
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3 Cited Publications
Art. -Nr.: HY-32736
CAS. Nr.: 38647-11-9
Synonyms: NSC 165677; PG 492
Category:  

Terpenoids Celastraceae Diterpenoids Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology

Target:  

Wnt β-catenin Apoptosis Autophagy

Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC50 of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects .
3
Corynoxine
Corynoxine
0 Images
3 Cited Publications
Art. -Nr.: HY-N0901
CAS. Nr.: 6877-32-3
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids

Target:  

Autophagy

Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .
1
Geissoschizine methyl ether
Geissoschizine methyl ether
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1 Cited Publications
Art. -Nr.: HY-N2411
CAS. Nr.: 60314-89-8
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids

Target:  

5-HT Receptor

Geissoschizine methyl ether is an orally active, blood-brain barrier permeable alkaloid, and a partial agonist of the 5-HT1A receptor. It can be isolated from Uncaria hook. Geissoschizine methyl ether potently inhibits the binding of [ 3H]8-OH-DPAT to the 5-HT1A receptor in a concentration-dependent manner, with an IC50 of 0.904 μM. It ameliorates isolation-induced increased aggression and reduced sociability in mice. Geissoschizine methyl ether promotes oligodendrocyte differentiation and remyelination in the medial prefrontal cortex of adult mice .
Ilexoside D
Ilexoside D
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Art. -Nr.: HY-N5037
CAS. Nr.: 109008-27-7
Category:  

Cardiovascular Disease Aquifoliaceae Triterpenes Terpenoids Plants Disease Research Fields Tabernaemontana elegans Stapf

Target:  

Others

Ilexoside D is isolated from the roots of Ilex pubescens Hook. et Arn. Ilexoside D has the anti-tissue factor activity as well as the antithrombotic activity .
Glabranine
Glabranine
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Art. -Nr.: HY-N3942
CAS. Nr.: 41983-91-9
Category:  

Infection Flavonoids Leguminosae Flavonones Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch.

Target:  

Flavivirus Dengue Virus HIV

Glabranine, an flavonoid, is isolated from Tephrosia s.p, exerts a inhibitory effect in vitro on the dengue virus . Glabranine forms interaction with the soluble ectodomain of DENV type 2 (DENV2) E protein .
Wilforlide A
Wilforlide A
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Art. -Nr.: HY-N0476
CAS. Nr.: 84104-71-2
Synonyms: Regelide; Abruslactone A
Category:  

Triterpenes Terpenoids Celastraceae Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology

Target:  

Others

Wilforlide A is a bioactive triterpene isolated from Tripterygium wilfordii Hook f. Wilforlide A has anti-inflammatory and immune suppressive effects .
PROTAC Chk1 degrader-1
PROTAC Chk1 degrader-1
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Art. -Nr.: HY-161108
CAS. Nr.: 2597167-34-3
Target:  

PROTACs Checkpoint Kinase (Chk)

Forschungsgebiete:  

Cancer

PROTAC Chk1 degrader-1 is a Chk1-targeting PROTAC.PROTAC Chk1 degrader-1 recruits the Cereblon E3 ligase to induce ubiquitination and proteasomal degradation of Chk1.PROTAC Chk1 degrader-1 exhibits Chk1 degradation activity in malignant melanoma cells without showing a hook effect.PROTAC Chk1 degrader-1 can be used for the research of malignant melanoma .
Laetanine
Laetanine
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Art. -Nr.: HY-N4307
CAS. Nr.: 72361-67-2
Category:  

Infection Alkaloids Phenols Polyphenols Plants Lauraceae Disease Research Fields Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm.

Target:  

Parasite

Laetanine is a noraporphine alkaloid from Litsea laeta, exhibits antiplasmodial activity. Laetanine can be found in the extract of the leaves of Phoebe tavoyana (Meissn) Hook .
Wilforgine
Wilforgine
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Art. -Nr.: HY-N1072
CAS. Nr.: 37239-47-7
Category:  

Terpenoids Sesquiterpenes Celastraceae Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology

Target:  

Calcium Channel

Wilforgine is a bioactive sesquiterpene alkaloid in Tripterygium wilfordii Hook. F. Wilforgine can induce microstructural and ultrastructural changes in the muscles of Mythimna separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system .
STING Degrader-1
STING Degrader-1
0 Images
Art. -Nr.: HY-162331
Target:  

Molecular Glues STING

Forschungsgebiete:  

Inflammation/Immunology Cancer

STING Degrader-1 (compound 2), a molecular glue, is a potent STING degrader that covalently binds to STING and E3 ligase. STING Degrader-1 exhibits a "hook effect", that degrades 75% STING protein at 10 μM, and degrades ca. 30% STING protein at 30 μM .
Ilexsaponin B2
Ilexsaponin B2
0 Images
Art. -Nr.: HY-N6256
CAS. Nr.: 108906-69-0
Category:  

Cardiovascular Disease Aquifoliaceae Triterpenes Terpenoids Plants Disease Research Fields Tabernaemontana elegans Stapf

Target:  

Phosphodiesterase (PDE)

Ilexsaponin B2 is a saponin isolated from the root of Ilex pubescens Hook. et Arn. Ilexsaponin B2 is a potent phosphodiesterase 5 (PDE5) and PDEI inhibitor with IC50 values of 48.8 μM and 477.5 μM, respectively .
Triptonide (Standard)
Triptonide (Standard)
0 Images
Art. -Nr.: HY-32736R
CAS. Nr.: 38647-11-9
Synonyms: NSC 165677 (Standard); PG 492 (Standard)
Category:  

Terpenoids Celastraceae Diterpenoids Plants Tripterygium wilfordii Hook. f.

Target:  

Reference Standards Wnt β-catenin Apoptosis Autophagy

Triptonide (Standard) is the analytical standard of Triptonide. This product is intended for research and analytical applications. Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC50 of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects .
IBI-325
IBI-325
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Art. -Nr.: HY-P991634

Target:  

CD73 TNF Receptor Interleukin Related IFNAR

Forschungsgebiete:  

Inflammation/Immunology Cancer

IBI-325 is a humanized monoclonal antibody inhibitor targeting CD73. IBI-325 completely inhibits CD73 enzymatic activity without hook effect. IBI-325 reverses Adenosine monophosphate (HY-A0181)-mediated immune suppression and significantly inhibits T cell proliferation and cytokines (IL-2, IFN-γ and TNF-α) release. IBI-325 has potent antitumor activities in hPBMC-reconstituted mice model and hCD73 knock-in mice model. IBI-325 can be used for cancer immunotherapy research .
HOOK1 Human Pre-designed siRNA Set A
HOOK1 Human Pre-designed siRNA Set A
Art. -Nr.: HY-RS06287
Target:  

Small Interfering RNA (siRNA)

Forschungsgebiete:  

Others

HOOK1 Human Pre-designed siRNA Set A contains three designed siRNAs for HOOK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HOOK2 Human Pre-designed siRNA Set A
HOOK2 Human Pre-designed siRNA Set A
Art. -Nr.: HY-RS06288
Target:  

Small Interfering RNA (siRNA)

Forschungsgebiete:  

Others

HOOK2 Human Pre-designed siRNA Set A contains three designed siRNAs for HOOK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HOOK3 Human Pre-designed siRNA Set A
HOOK3 Human Pre-designed siRNA Set A
Art. -Nr.: HY-RS06289
Target:  

Small Interfering RNA (siRNA)

Forschungsgebiete:  

Others

HOOK3 Human Pre-designed siRNA Set A contains three designed siRNAs for HOOK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Triptonoterpene Me ether
Triptonoterpene Me ether
0 Images
Art. -Nr.: HY-N12212
CAS. Nr.: 173293-35-1
Category:  

Terpenoids Celastraceae Diterpenoids Plants Tripterygium wilfordii Hook. f.

Target:  

Others

Triptonoterpene Me ether (compound 5) is a rosinane-type diterpenoid compound, which can be isolated from the traditional Chinese medicine Tripterygium wilfordii Hook. f .
(Rac)-Tephrosin
(Rac)-Tephrosin
0 Images
Art. -Nr.: HY-N1166A
CAS. Nr.: 561-35-3
Category:  

Flavonoids Leguminosae Isoflavanones Plants Tephrosia purpurea (L.) Pers.

Target:  

Others

(Rac)-Tephrosin is a natural product that can be found in Tephrosia purpurea .
Triptonoterpene
Triptonoterpene
0 Images
Art. -Nr.: HY-N10406
CAS. Nr.: 99694-87-8
Category:  

Other Terpenoids Celastraceae Diterpenoids Plants Tripterygium wilfordii Hook. f.

Target:  

Others

Triptonoterpene is a natural product that can be isolated from the roots of Tripterygium wilfordii Hook. f. .
Assay Types